iS CLINICAL
iS CLINICAL is a pharmaceutical-grade cosmeceutical brand collection by Innovative Skincare LLC, founded by biochemists Bryan Johns and Alec Call in 2000 in Burbank, California. The brand is built on patented Extremozyme® technology — enzymes derived from plants that survive in extreme climates and protect the skin at DNA level.
Formulas are produced in the brand's own Burbank laboratory with seven quality-control stages, and each product has been independently reviewed in clinical studies. Trusted by professionals in more than 125 countries. Available in our e-shop and at the Skinmedik salon in Riga.
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Why choose iS CLINICAL skincare?
iS CLINICAL combines pharmaceutical-grade manufacturing standards with botanical active compounds of the highest purity. Each product is formulated and manufactured at the brand’s own facility in Burbank, California, where seven quality-control stages ensure pharmaceutical purity and consistency. All products have been independently reviewed in clinical studies and are trusted in dermatology, plastic surgery and medical aesthetics practices in more than 125 countries, including the Mayo Clinic shop.
The collection includes products that provide:
- DNA-level protection. Extremozyme® technology uses enzymes from plants that live in extreme conditions to neutralise environmental stressors and delay skin-cell ageing at chromosomal level.
- Radiance and renewal. GeneXC® serum combines 20% L-ascorbic acid with Extremozymes and marine antioxidants — helping to even skin tone, improve texture and restore radiance.
- A clinically validated four-step system. Cleanse — treat — moisturise — protect: each step has been clinically tested for all skin types, tones and age groups, including oncology patients (iS Cancer Care® programme).
- Pharmaceutical purity without compromise. The formulas contain no parabens, phthalates or sulphates; 95–98% of the active ingredients are botanical in origin and of the highest purity available — with no third-party manufacturing.
The Innovative Skincare heritage
Before founding iS CLINICAL, biochemist Bryan Johns led the skincare division at the prestigious Kronos Institute — one of the world’s leading anti-ageing research centres. His academic background in biochemistry, psychology and genetics (University of California, San Diego) shaped an approach that brings botanical science and clinical research together in a single framework. Together with Alec Call, Innovative Skincare LLC has grown from a Burbank laboratory into a globally recognised brand whose founders have supported the National Breast Cancer Coalition (NBCC) for more than ten years.
Choose iS CLINICAL in our online shop or at the Skinmedik salon in Riga to enjoy clinically tested, pharmaceutical-grade skincare every day, with visible and long-lasting results.